Depression-like behavioral analysis in CGRP Transgenic mice
نویسندگان
چکیده
منابع مشابه
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes proteolytic cleavage in AD brains and in cultured neuronal cells, resulting in the accumulation of carboxyl-terminal-truncated fragments of apoE that are neurotoxic. Here we show that this fragmentat...
متن کاملBehavioral effect of naloxone on anxiolytic- like effect of noscapine in bulb/c mice
The effect of naloxone, a non-selective opioid antagonist on some anxiolytic and analgesic drugs is reported. Noscapine is an opioid alkaloid with antitussive effect that cannot be antagonized by naloxone. The anxiolytic-like effect of noscapine has been shown in light-dark model and elevated plus maze. In this study the effect of naloxone on anxiolytic effect of noscapine in light-dark model w...
متن کاملBehavioral effect of naloxone on anxiolytic- like effect of noscapine in bulb/c mice
The effect of naloxone, a non-selective opioid antagonist on some anxiolytic and analgesic drugs is reported. Noscapine is an opioid alkaloid with antitussive effect that cannot be antagonized by naloxone. The anxiolytic-like effect of noscapine has been shown in light-dark model and elevated plus maze. In this study the effect of naloxone on anxiolytic effect of noscapine in light-dark model w...
متن کاملBehavioral and Biochemical Evidences for Antidepressant-Like Activity of Celastrus Paniculatus Seed Oil in Mice
Introduction: Celastrus paniculatus seed oil, commonly known as Malkangni or Jyotishmati, was in use from time immemorial to treat brain related disorders. Celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. The present study was undertaken to evaluate the antidepressant-like effect of Celastrus paniculatus seed oil ...
متن کاملBehavioral assessments of auditory sensitivity in transgenic mice.
This report summarizes positive reinforcement conditioning procedures for assessing sensory function in transgenic mice. To illustrate these behavioral methods auditory sensitivity was measured in mice lacking alpha9 acetylcholine receptor subunits (alpha9 knock-out mice). These receptors are known to play an important role in the efferent pathways that modify cochlear responses to sound stimul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2019
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.92.0_3-p-032